منابع مشابه
Forced Degradation Studies of Aloe Emodin and Emodin by HPTLC.
Anthraquinones are natural phenolic compounds, which are reported to act as anti-aging, anti-inflammatory, antioxidant, anti-cancer, laxative and antitumor agents. They are abudant in plants like candle bush, aloes, cascara bark and rhubarb. The present work was to observe the effect of different forced degradation conditions by high-performance thin layer chromatography on potential markers i....
متن کاملUse of Forced Degradation Studies on S-(−)-Amlodipine Besylate to Generate Information on the Degradation Products
Amlodipine is a long-acting calcium channel blocker used in the treatment of hypertension and angina pectoris. S-(−)-amlodipine besylate is a safer and longer-acting alternative to the existing racemate [1]. Although several products based on the active enantiomer have reached the market, information on its chemical, physical and thermal stability during storage is lacking [2, 3]. The objective...
متن کاملDevelopment of forced degradation and stability indicating studies of drugs—A review
Forced degradation is a degradation of new drug substance and drug product at conditions more severe than accelerated conditions. It is required to demonstrate specificity of stability indicating methods and also provides an insight into degradation pathways and degradation products of the drug substance and helps in elucidation of the structure of the degradation products. Forced degradation s...
متن کاملForced Degradation Studies of Ivabradine and In Silico Toxicology Predictions for Its New Designated Impurities
All activities should aim to eliminate genotoxic impurities and/or protect the API against degradation. There is a necessity to monitor impurities from all classification groups, hence ivabradine forced degradation studies were performed. Ivabradine was proved to be quite durable active substance, but still new and with insufficient stability data. Increased temperature, acid, base, oxidation r...
متن کاملFour new degradation products of doxorubicin: An application of forced degradation study and hyphenated chromatographic techniques☆
Forced degradation study on doxorubicin (DOX) was carried out under hydrolytic condition in acidic, alkaline and neutral media at varied temperatures, as well as under peroxide, thermal and photolytic conditions in accordance with International Conference on Harmonization (ICH) guidelines Q1(R2). It was found extremely unstable to alkaline hydrolysis even at room temperature, unstable to acid h...
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ژورنال
عنوان ژورنال: Journal of Analytical & Pharmaceutical Research
سال: 2016
ISSN: 2473-0831
DOI: 10.15406/japlr.2016.03.00073